At least four people were killed Thursday morning when a U.S. predator drone targeted a house in the Miranshah area of North Waziristan Agency.
According to the media reports, the U.S. drone fired two missiles at the house in which four people were killed on the spot.
The house was completely destroyed in the attack while some nearby houses also got damaged.
According to the eyewitnesses, two drones took part in the attack, one fired missiles at the house while the other hovered over the area.
Local tribal people rushed to the spot after the attack and started rescue work.
The identities of the victims are still unknown.
On Wednesday evening, four people were killed when US drones targeted two vehicles by firing four missiles in the same region.
It was the 22nd drone strike of its kind since the start of this year in which at least 159 people were reportedly killed.