MIRANSHAH (AFP) - A US drone strike killed at least four insurgents Wednesday at a compound in North Waziristan Agency, security officials said. The attack was the third since Sunday in the agency, a stronghold of the Taliban, Al-Qaeda and Haqqani network. Officials and residents said the aircraft fired two missiles into a militant compound in Tabi Tolkhel village, just five kilometres from the border with the Afghan province of Khost. According to initial reports four militants were killed and two wounded, a security official said, requesting anonymity. A local administration official confirmed the toll and said it was a US drone strike targeting a compound belonging to a Taliban commander. The building was used as a guesthouse for visiting Taliban militants operating across the border in Afghanistan, another security official said. Khost was the scene of a suicide attack in December, when a Jordanian double agent infiltrated a US base and blew himself up, killing seven CIA employees in the deadliest attack on the US spy agency in 26 years. More than 780 people have been killed in the US strikes in Pakistan since August 2008, with a surge in the past year as US President Barack Obama puts Pakistan at the heart of his fight against Al-Qaeda.