MIAMI (Florida) (AFP) World No. 1 and top seed Roger Federer was sent crashing out of the ATP and WTA Masters tournament dropping a 6-4, 6-7 (3/7), 7-6 (8/6) fourth round marathon contest to Czech Tomas Berdych. Federer struggled to find his form on Tuesday in an almost three hour match in front of a record crowd of 12,084 on the hardcourts at Crandon Park. I fought as much as I could, Federer said. My game has issues at the moment. Im definitely lacking timing. I dont know where that comes from. The reigning Australian Open champion suffered just his second loss to Berdych in 10 career meetings. Berdych, the 16th seed, saved one match point in a third set tiebreaker. He hammered six aces and won 67 percent of his first service points to snap an eight match losing streak to the Swiss superstar. The feeling is great, the Czech said. Im really extremely happy, you know. With Roger, you have to be always 100 percent ready. Hes fighting until the last point. Six-time Grand Slam champ Rafael Nadal and American Andy Roddick were two of eight seeded players to advance to the quarter-finals Tuesday. Nadal, who is playing in just his fourth tournament of the season, outlasted fellow Spaniard David Ferrer 7-6 (7/5), 6-4. With each round it gets more difficult, Nadal said. I had my moments today but I also had moments where I made more mistakes than usual but it was an important win. Federer, who has 16 Grand Slam titles, was also knocked out in the third round of his last tournament two weeks ago at Indian Wells and had to withdraw from the Dubai event last month with a lung infection. Berdych reached his fifth quarter-final of the season and now has a 15-7 record this season. He lost to Nadal in the quarters at Indian Wells and made the semis at Brisbane before being eliminated by Roddick. Just five of the top ten and two of the top five seeds remain in the draw as the only two unseeded players were eliminated on Tuesday. Nadal won the first set in a tiebreak then raced out to a 3-0 lead in the second before Ferrer rallied in the one hour, 57 minute match. Nadal, who is an impressive 15-3 this year, is coming off a semi-final finish and a doubles title at Indian Wells two weeks ago. It was his first tournament since retiring in the quarters of the Aussie Open because of a right knee injury. Nadal next faces Frenchman Jo-Wilfried Tsonga, against whom he owns a 4-1 lead in their head-to-head series. But Tsonga recorded an impressive win over Nadal in the 2008 Australian Open semi-finals. The winner of the Nadal-Tsonga match will play the winner of the Andy Roddick-Nicolas Almagro quarter-final. He has a big serve and a very good forehand, Nadal said of Tsonga. It is going to be a tough match because he is playing well right now. Former champion Roddick continued his mastery over Benjamin Becker by beating the unseeded German 7-6 (6/4), 6-3. Roddick, who is seeking his first win here since 2004, improved to 23-4 this year and advanced to his seventh quarter-final in 11 previous appearances in the event. Also, in the mens fourth round, American Mardy Fish - who knocked out Andy Murray in the second round - retired with a back injury trailing Mikhail Youzhny 6-1, 1-0. Roland Garros finalist Robin Soderling reached the Miami quarter-finals for the first time with a 6-0, 6-7 (7/3), 6-2 win over Chilean Fernando Gonzalez. Eighth seeded Tsonga beat No. 12 Juan Carlos Ferrero 6-2, 6-2, and Nicolas Almagro eliminated Thomaz Bellucci 6-4, 3-6, 7-6 (7/3). In womens play, Venus Williams, who is the oldest womens quarter-finalist at 29, beat Agnieszka Radwanska 6-3, 6-1 to advance to the semis. When Im executing and playing my best, its great, said Venus, who is bidding to win her fourth Key Biscayne title and first in nine years. It feels good, and I feel like Im definitely dictating the points and that I dont give my opponent as many chances to have a say. Third seeded Venus has won 14 matches in a row, and two more would give her three straight tournament titles for the first time since 2002. She hammered eight aces and lost only five points on her first serve. She struggled with her backhand but won 15 of 19 net points to reach the semis where she will face Frances Marion Bartoli who beat Yanina Wickmayer 6-4, 7-5. I play my best game when Im more aggressive, because thats my style, she said. Others dont play as well as aggressively, because thats not their style. It just seems to be better when I move forward, and I try to do that.