LONDON - Defending champion Andy Murray reached his seventh successive Wimbledon quarter-final Monday with a straight sets demolition of Kevin Anderson under the Centre Court roof while torrential rain brought more chaos to his rivals.

Third-seeded Murray defeated the big-serving South African 6-4, 6-3, 7-6 (8/6) with 11 aces and 49 winners and next faces Bulgarian 11th seed Grigor Dimitrov who beat Leonardo Mayer of Argentina 6-4, 7-6, 6-2 for a place in the semi-finals.

The third-seeded Australian Open champion defeated Uzbekistan's Denis Istomin 6-3, 6-3, 6-4 to reach the fourth round for the first time since 2009. Wawrinka will now play his fourth round on Tuesday against 19th seed Feliciano Lopez of Spain who also waited until Monday to see off John Isner, the ninth seeded American, 6-7 (8/10), 7-6 (8/6), 7-6 (7/3), 7-5. Victory on Tuesday would mean a quarter-final on Wednesday before getting back on schedule for semi-final day on Friday and a potential final date on Sunday.

In the remaining third round match to be completed, Nishikori saw off Italian lucky loser Simone Bolelli 3-6, 6-3, 4-6, 7-6 (7/4), 6-4 after the pair had finished 3-3 in the decider on Saturday. In his maiden last-16 appearance, Nishikori will face Canadian eighth seed Milos Raonic on Tuesday.

Isner's defeat to Lopez meant that no America man or woman had reached the fourth round at Wimbledon for the first time since 1911. Later Monday, top seed Novak Djokovic takes on flamboyant Frenchman Jo-Wilfried Tsonga. Djokovic or Tsonga will play Croatian 26th seed Marin Cilic for a place in the semi-finals. Cilic reached the quarter-finals for the first time with a 7-6 (10/8), 6-4, 6-4 win over France's Jeremy Chardy.

Russia's Ekaterina Makarova sent former finalist Agnieszka Radwanska crashing to a surprise exit at Wimbledon on Monday, while giant-killer Barbora Zahlavova Strycova claimed another famous scalp to lead a triple Czech charge into the quarter-finals.

Makarova, the 22nd seed, had never been past the third round in her six previous appearances at Wimbledon, while Polish fourth seed Radwanska made the final in 2012, losing to Serena Williams, and then the last four 12 months ago. But the 26-year-old, a quarter-finalist at the Australian and French Opens last year, destroyed the world No 4 on Court Three and will play Czech 23rd seed Lucie Safarova for a place in the semi-finals.

Radwanska's exit means three of the top four seeds have been eliminated from the women's draw following the defeats of Williams and Li Na. Earlier, Zahlavova Strycova moved into the last eight with a 6-2, 7-5 victory against former world No 1 Caroline Wozniacki. Zahlavova, the world No 43, had enjoyed the best win of her career in the previous round when she defeated Chinese second seed Li and she added Danish 16th seed Wozniacki to her list of upsets, converting a sixth match point to move into the last eight at a Grand Slam for the first time at the 32nd attempt. The 28-year-old will play compatriot Petra Kvitova for a place in the semi-finals.

Czech sixth seed Petra Kvitova routed world No 61 Peng Shuai of China 6-3, 6-2 in just one hour on Court Two. She has now reached the last eight at Wimbledon for five successive years. Three of the four quarter-finalists in the bottom half of the draw are Czech after Safarova ended the fairytale run of world No 175 Tereza Smitkova with a 6-0, 6-2 victory in just 47 minutes. Safarova will face Makarova in her first Wimbledon quarter-final appearance. Canadian star Eugenie Bouchard booked her first appearance in the quarter-finals as the 13th seed defeated Alize Cornet 7-6 (7/5), 7-5.

Sabine Lisicki, last year's beaten finalist, finally downed former world No 1 Ana Ivanovic on Monday to give herself a place in the last 16. She beat the Serbian 11th seed 6-4, 3-6, 6-1. She faces Kazakhstan's Yaroslava Shvedova on Tuesday for a place in the quarter-finals.