WASHINGTON (AFP) - President Barack Obama's signature attempt to resuscitate the recession-hit US economy risks running into an opposition wall in the Senate this week, top Republicans warned Sunday. With the Senate poised to take up the 819-billion-dollar stimulus package Monday, Republican elders said they would stall the bill without a fundamental rethink of its mix of spending and tax cuts. "In the Senate, it routinely takes 60 votes to do almost everything. It doesn't necessarily mean you're trying to slow a bill down," Senate Minority Leader Mitch McConnell said on CBS program "Face the Nation." "But a super-majority is required for virtually everything in the Senate, and certainly for something that is close to a one trillion dollar spending bill, it will," he said. To overcome a Republican "filibuster," the Democrats would need to amass 60 votes to shut down debate and bring the bill to a vote. Obama's party can now count on 58 votes to the Republicans' 41, with one seat still unresolved. Republicans, accusing the Democratic majority in Congress of shutting them out of debate, have resisted a charm offensive from the new president as he battles to enact the most pressing legislative item of his fledgling term. Last Wednesday the House of Representatives approved the gargantuan stimulus without a single Republican vote. Negotiations were carrying on through the weekend, as Obama invited a bipartisan group of lawmakers to the White House to watch the American football Super Bowl Sunday night. Jon Kyl, the Republicans' second-ranking senator, called for Obama and his Senate allies to "start from scratch" on the stimulus bill. "I think the more people around the country see of it, the angrier they get, because it's very wasteful. It spends way too much money," he said on "Fox News Sunday." "And so I see support in the Senate actually eroding." A key Republican demand is to refocus the stimulus package away from a spending spree on infrastructure and social safety nets towards attacking the root cause of the financial crisis: the US property market slump. Obama said Saturday that Treasury Secretary Tim Geithner would soon announce measures to free up credit for businesses and homeowners " but has stressed that such measures will come in a separate bailout for the banking industry. In his weekly radio address, the president urged the Senate to quickly tackle the "unprecedented economic turmoil," and vowed to "continue working with both parties so that the strongest possible bill gets to my desk." "With the stakes so high we simply cannot afford the same old gridlock and partisan posturing in Washington," he said. Obama's remarks came after Friday's release of dire figures showing that the US economy shrank by nearly four percent in the last quarter of 2008, its sharpest decline since 1982. Democratic senators, while reinforcing the message that speed is of the essence, said they were open to their Republican colleagues' ideas. "We said to them we're open about this. Let's move forward," Senator Richard Durbin said on Fox. On "Face the Nation," Senator Charles Schumer said he was confident of winning over enough Republican support. "But I will say this. I'd rather have a really good bill that helps our economy get out of this mess, with 65 votes, than dilute the bill and get 80 votes," he said. Opposition threats of a filibuster risk being undermined by Obama's expected nomination of Republican Senator Judd Gregg to serve as his commerce secretary. But McConnell, without going into details, said he had assurances that whoever replaces Gregg would vote with the Republicans, "so I think it would have no impact on the balance of power in the Senate."