PARIS   -   Japan’s Naomi Osaka gets up after slipping during her third round match of the French Open tennis tournament against Katerina Siniakova of the Czech Republic at the Roland Garros stadium in Paris, Saturday, June 1, 2019. Osaka lost her match in two sets, 4-6, 2-6. (AP Photo/Michel Euler)

This was one deficit too big to overcome for Naomi Osaka, whose Grand Slam winning streak is over. The No. 1-ranked Osaka couldn’t muster a comeback after falling way behind yet again at the French Open, losing 6-4, 6-2 in the third round to No. 42 Katerina Siniakova of the Czech Republic on Saturday. “I just feel like there has been a weight on me, kind of,” said Osaka, who was seeded No. 1 at a major tournament for the first time. She had won her past 16 matches at majors, allowing her to lift the trophies at the U.S. Open last September and Australian Open in January. That run also included two victories at Roland Garros after trailing by a set and a break each time. “I could see,” Siniakova said, “that she’s not so confident like she was.”

The loss ends Osaka’s run of 16 straight wins in Grand Slam tournaments, which included titles at the U.S. Open and Australian Open. Osaka’s exit, a day after No. 2 Karolina Pliskova lost, leaves defending champion Simona Halep, at No. 3, as the highest-seeded woman remaining. Halep needed only 55 minutes to get to the fourth round with a 6-2, 6-1 victory over No. 27 Lesia Tsurenko. Keys, a semifinalist in Paris a year ago, advanced by beating qualifier Anna Blinkova 6-3, 6-7 (5), 6-4.

In men’s action, No. 1 Novak Djokovic stretched his Slam winning streak to 24 matches as he seeks his fourth title in a row, eliminating 147th-ranked qualifier Salvatore Caruso of Italy 6-3, 6-3, 6-2.

Also advancing were No. 5 Alexander Zverev, No. 6 Stefanos Tsitsipas, No. 9 Fabio Fognini and No. 24 Stan Wawrinka, the 2015 champion and 2017 runner-up at Roland Garros. Djokovic barely broke a sweat as he is in fourth round without dropping aset. Djokovic has never lost a Grand Slam match to a player ranked as low as Caruso, and never showed any sign of doing so on Saturday, breezing to a two match-point advantage in little over two hours. He only needed one of those to put Caruso, ranked 147 in the world, out his misery.

The Serbian is yet to drop a set in the tournament and has rarely had such an easy run into the fourth round at Roland Garros. He will face either Germany’s Jan-Lennard Struff or 13th seed Borna Coric of Croatia next.