At least ten persons were killed and several others injured when a US drone attacked a house in North Waziristan Agency on early Saturday morning.

A US drone attack targeting a militant compound killed at least 10 militants in North Waziristan early Saturday, security officials said

The officials said two missiles hit and destroyed the compound in Shawal area, some 70 kilometres (45 miles) west of Miranshah, the main town in North Waziristan.

"The death toll in the US drone strike has risen to 10. The drone fired two missiles at the compound," a security official in Peshawar told AFP. Two security officials in Miranshah confirmed the strike and death toll and added that militants were using the compound as a training centre. They said the mud compound was completely destroyed. Officials had earlier put the death toll at six. The identity of those killed in the strike was yet not known and officials said they were trying to collect more information from the far-flung mountainous area.

Saturday's attack was the second strike since parliament in March approved new guidelines on relations with the United States, which included a call for an end to drone attacks on Pakistani territory.

Pakistan says the drone strikes are counter productive and undermine government efforts to separate tribes from militants, violate Pakistan's sovereignty, kill civilians and fuel anti-US sentiment.

Pakistan raised the issue with Marc Grossman, the US special representative for Afghanistan and Pakistan, when he visited Islamabad last month amid efforts to mend fractured relations.

Saturday's U.S. drone strike is the 12th of its kind in Pakistan since this year. Up to date, at least 93 people have reportedly been killed in such strikes in 2012. According to an AFP tally, 45 US missile strikes were reported in Pakistan's tribal belt in 2009, the year Obama took office, 101 in 2010 and 64 in 2011. The New America Foundation think-tank in Washington says drone strikes have killed between 1,715 and 2,680 people in Pakistan in the past eight years.