DAMASCUS - Syrian President Bashar al-Assad has vowed to retake an area that supplies Damascus with water and rejected any negotiations on his departure at upcoming talks in Kazakhstan.

Millions of people have been without water for weeks after fighting damaged key infrastructure in the Wadi Barada region outside Damascus that is the main water source for the capital.

The government says former Al-Qaeda affiliate Fateh al-Sham Front, known previously as Al-Nusra Front, is present in Wadi Barada, and blames rebels there for cutting water to Damascus since December 22. "The role of the Syrian Army is to liberate that area in order to prevent those terrorists from using that water in order to suffocate the capital," Assad told French media in an interview aired Monday. Assad's forces have been battling rebels in Wadi Barada for weeks and the fighting has continued despite the start on December 30 of a nationwide ceasefire brokered by Russia and Turkey.

Assad said the ceasefire was being "breached on a daily basis" and mainly around Damascus "because the terrorists occupy the main source of water" in Wadi Barada. He said "more than five million civilians have been deprived of water for the last three weeks" as a result of the fighting. The United Nations says 5.5 million people in and around Damascus are without water.

Assad said that Fateh al-Sham is "occupying" the Wadi Barada region, 15 kilometres (10 miles) northwest of the capital. But rebels deny that the militants are in the area and say the water supply was severed after government strikes hit pumping facilities.

Assad also insisted that the ceasefire does not include Fateh al-Sham or its formidable rival, the Islamic State group.

On Monday, regime forces and fighters from Lebanon's Shiite movement Hezbollah clashed with rebels and some Fateh Al-Sham militants in the Wadi Barada area, the Syrian Observatory for Human Rights said.

On Sunday, two civilians were killed by regime fire and the area was hit by a dozen regime air raids after the failure of negotiations to repair the water plant at Ain al-Fijeh, the Britain-based monitor said.

Assad also rejected any negotiations towards his departure from power at talks set to be held in late January in Kazakhstan's capital Astana.

"My position is related to the constitution, and the constitution is very clear about the mechanism in which you can bring a president or get rid of a president," he said.

"So, if they (the opposition) want to discuss this point, they have to discuss the constitution, and the constitution is not owned by the government or the president or by the opposition.

"It should be owned by the Syrian people, so you need a referendum," he said.

The Astana talks, organised by regime allies Russia and Iran and rebel backer Turkey, aim to pave the way towards an end to a nearly six-year war that has killed 310,000 people and displaced millions.

Assad has said Syrian forces are on their way to victory after they recaptured the northern city of Aleppo on December 22 with support from Moscow and Tehran.

Opposition negotiator Basma Khodmani said: "This time the Russians are serious and determined. They want to get out of the conflict. They have gone as far as it was in their interest to go on the military front."

"They can't obtain a total victory as it would take years. They now want a political solution and this Astana meeting to be credible."

Since it started with the brutal repression of anti-government protests in 2011, Syria's uprising has evolved into a complex war involving many players.

Commandos from the US-led coalition battling the Islamic State group have raided a village held by the militants in eastern Syria, a monitor and the US-backed Syrian Democratic Forces said Monday.

US Central Command told AFP that "an operation was conducted in that area", but declined to give further details.

At least 25 militants were killed in the two-hour raid, the Syrian Observatory for Human Rights monitor said.

"Four helicopters from the international coalition yesterday (Sunday) at noon carried out a commando raid on Al-Kubar village in western Deir Ezzor province," Observatory director Rami Abdel Rahman told AFP.

The oil-rich eastern province, which borders Iraq, is almost totally under IS control and has been regularly targeted by US-led forces.

Coalition forces targeted a bus carrying 14 IS fighters, killing them all, Abdel Rahman said.

They also targeted an IS-controlled water facility in the village, killing at least 11 militants in a firefight.

A commander of the SDF, a US-backed coalition of Arab and Kurdish forces, confirmed the raid on the village, 40 kilometres (25 miles) from Deir Ezzor city.

"Four American Apache helicopters and two back-up helicopters, carried out a commando raid" in Al-Kubar on Sunday at noon, he said.

The attack targeted vehicles driven by senior IS fighters coming from Raqa, killing several and capturing others, he added.

A Syrian army official said military radars had detected the operation but could not identify the nationality of the aircraft.

The US has been leading a campaign against IS in Syria since September 2014.

Deir Ezzor is Syria's second biggest province after Homs. Since early 2015 the militants have besieged the provincial capital, also called Deir Ezzor, home to some 200,000 people.

IS controls around 60 percent of the city, the rest of which is held by forces loyal to Syrian President Bashar al-Assad.