WASHINGTON: Living to the ripe old age of 500 might be a possibility if the science shown to extend worms’ lives can be applied to humans, scientists have said. US researchers tweaked two genetic pathways in the tiny lab worm Caenorhabditis elegans and boosted the creature’s lifespan by a factor of five. The research raises the prospect of anti-ageing treatments based on genetic interactions, they said.
What we have here is a synergistic five-fold increase in lifespan ,’ said lead scientist Dr Pankaj Kapahi, from the Buck Institute of Age Research, Novato, California. While it could take years of research to extend humans’ lives dramatically, the study raises the prospect of anti-ageing treatments informed by genetic interactions, according to Dr Kapahi.
‘In the early years, cancer researchers focused on mutations in single genes, but then it became apparent that different mutations in a class of genes were driving the disease process,’ he said. The same thing is likely happening in ageing,’ he added. C. elegans, the first animal to have its whole genome (or genetic code) mapped, has been widely used in studies of ageing and lifespan . The new research, reported in the journal Cell Reports, involved blocking key molecules that affect the action of insulin and a nutrient signalling pathway called Target of Rapamycin (TOR).–AFP
Single mutations in the TOR pathway were known to extend the lifespan of C. elegans by 30 per cent, while insulin-signalling mutations could double the amount of time they lived. Adding the two together might have been expected to extend longevity by 130 per cent, but the combined impact turned out to be much greater. The research may explain why it has proved so difficult to identify single genes responible for the long lives enjoyed by human centenarians.–MOL