London - Misfiring Manchester United crashed to a third consecutive defeat on Sunday as manager Jose Mourinho saw his side deservedly beaten 3-1 at Watford in the Premier League.

It is the first time Mourinho has lost three straight games within the same season since he was at Porto in 2002 and it left United six points behind early pace-setters Manchester City.

Tottenham Hotspur went third after beating Sunderland 1-0 with a goal from Harry Kane, who later limped off. Crystal Palace crushed Stoke City 4-1 and Southampton edged Swansea City 1-0. "We started the season very well and had good results," said Mourinho. "I feel the first moment we had a defeat, a difficult situation, some of the boys are having a bit of difficulty coping with the negativity."

Marcus Rashford cancelled out Etienne Capoue's opener for Watford, but a late goal by Juan Camilo Zuniga and a stoppage-time Troy Deeney penalty gave Walter Mazzarri's side the three points. United were beaten 2-1 by Manchester City in their previous league game and then went down 1-0 to Feyenoord in the Europa League on Thursday.

Mourinho made five changes to the team that had lost in Rotterdam, with Antonio Valencia, Luke Shaw, Marouane Fellaini, Wayne Rooney and Zlatan Ibrahimovic coming in. But once again United made a sluggish start and they were given a big let-off when Odion Ighalo somehow curled wide of an open goal after visiting goalkeeper David de Gea dropped a high ball.

Paul Pogba cracked a dipping shot against the bar moments later, but United fell behind in the 34th minute when Daryl Janmaat cut the ball back for Capoue to sweep home his fourth goal of the campaign. Mourinho felt that United should have been awarded a free-kick for a foul on Anthony Martial by Miguel Britos in the build-up.

Martial landed heavily, having earlier been hurt in a clash of heads with Janmaat, and he left the pitch shortly after, with Ashley Young coming on. Rashford, making his first league start of the season, equalised just after the hour, slamming in from close range after Ibrahimovic's cross from the left bounced into his path.

But United were undone in the 83rd minute when Roberto Pereyra cut the ball back for substitute Zuniga, who exploited acres of space to curl a shot past De Gea with his first touch after coming on. Deeney sealed victory in the fifth minute of stoppage time, drilling a penalty into the net after Fellaini had caught Zuniga.

It was Watford's first victory over United in 30 years and saw them climb to ninth place. "It is a very important three points to give my players the confidence to go ahead," said Mazzarri, via an interpreter.

Tottenham leapt up to third place, four points below leaders City, after bouncing back from their opening Champions League loss to Monaco by sinking Sunderland at White Hart Lane. Kane settled the game in the 59th minute, slotting in from close range after Papy Djilobodji miscued an attempted clearance.

But there was bad news for manager Mauricio Pochettino as Kane hobbled off after seeming to roll his right ankle and had to be carried away on a stretcher. "We'll see tomorrow how his ankle is," Pochettino told Sky Sports. "I'm happy for him, but disappointed with his injury. The image was a little bit tough, but we need to assess tomorrow. We hope it's not a big issue for us."

Sunderland winger Adnan Januzaj was sent off in the last minute after picking up a second yellow card. Crystal Palace rose to eighth place after a breezy 4-1 win over bottom club Stoke City. James Tomkins, Scott Dann, James McArthur and Andros Townsend found the net for Palace before Marko Arnautovic claimed a consolation in stoppage time. Southampton moved out of the bottom three after Charlie Austin's second-half volley secured a 1-0 win over Swansea.