Seventeen candidates are contesting the by-poll including candidates of MQM-Pakistan, Pakistan Tehreek-e-Insaf and Pak Sarzameen Party.
The seat had fallen vacant due the death of PTI MNA, Dr Aamir Liaquat Hussain.
A total 263 polling stations have been set up by the election commission for the by-election, of which 60 polling stations have been declared sensitive and 203 most sensitive.
Strict security plan has been chalked out to maintain law and order on the polling day.