Washington-Scientists have developed a new chemical they claim can restore light sensitivity in blind mice. The compound, called DENAQ, acts as a “photoswitch” that can turn on light-sensitive cells in retinas when injected into the eyes. Each injection enabled blind mice to respond to normal levels of light perception for several days.

The authors of the study, published in Neuron, said the compound could potentially be used to treat human patients suffering from degenerative eye conditions such as age-related macular degeneration and retinitis pigmentosa - diseases caused by progressive degeneration of the receptors in our eyes that process light. Eye diseases such as these affect millions globally and there is currently no cure.

The retina has three layers of nerve cells, but only the outer layer contains the rod and cone cells that respond to light, enabling us to see the world. During the course of degenerative blindness, these rods and cones die. While the rest of the retina remains intact it is stripped of the functional photoreceptors - the rods and cones - and leaves sufferers unable to respond to light. Even though the nerve cells in the eye’s innermost layer remain connected to the brain, without the photoreceptors they can no longer transmit information useful for vision.

DENAQ makes these nerve cells in the retina respond to light by binding itself to proteins on their surface. When switched on by light, the chemical activates brain cells in much the same way as rods and cones are triggered. Mice with degenerated rods and cones that were injected with the compound became sensitive to light were able to detect light enough to influence behaviour in tasks set by researchers.

Getting regular injections in your eye may sound like an unpleasant experience, but the developers of the jab emphasise that it is a less invasive method that is more flexible than other technologies being developed to restore sight to people whose rods and cones have died. These include surgically injecting stem cells into the eyes to regenerate rods and cones, gene therapy, which uses a virus to insert a photoreceptor gene into “blind” neurons to make them sensitive to light, or installing prosthetic retinal devices.

The new compound is an improvement on earlier research where the same team created a chemical called AAQ. This performed a similar function of restoring light sensitivity in blind mice, but required bright ultraviolet light, making it unsuitable for medical use in humans.

“The new chemical DENAQ is a great improvement over our previous photoswitch AAQ,” Richard Kramer, professor of molecular and cell biology at the University of California, Berkeley, who led the study, said. “It responds to normal daylight-intensity, white light, it is non-toxic, and it persists in the eye for at least a few days.”