A US missile strike killed five people in the tribal area of South Waziristan here Sunday, report said. The attack hit in the Laddha region of South Waziristan, where Washington alleges Al-Qaeda and Taliban rebels who fled Afghanistan after the 2001 US-led invasion are holed up, plotting attacks on Western targets. "A drone attack targeting a vehicle killed five people in Mardar Algad area," Amir Mohammad Khan, local administration official in Laddha, informed a foreign news agency. The US military does not, as a rule, confirm drone attacks, but its armed forces and the Central Intelligence Agency operating in Afghanistan are the only forces that deploy drones in the region.